Lab news and links.
Juhyun's poster was selected for an oral presentation at the Third International Brainstorm Symposium hosted by the Center of NeuroGenetics at the University of Florida. Laura Ranum and Maury Swanson organized a thought-provoking few days of discussion on neurodegenerative diseases.
Maxime's paper showing that the transcriptional profiles of cortical projection neurons encode axonal projection pattern, laminar position within the cortex, and neural activity state was published in Cell Reports. This collaboration with the Goff laboratory used single cell RNA sequencing approaches to identify sources of transcriptional variation both within and between cortical cell types. The full article can be found here: DOI: 10.1016/j.celrep.2017.12.046
Jaclyn Frandolig will be attending SUNY Upstate Medical University in the fall to focus on primary care medicine.
Juhyun presented his work in the minisymposium on Deep-Layer Projection Neurons of the Neocortex: Specialized Subpopulations Exhibiting Distinct Integration and Output. Solange organized a minisymposium on New Breakthroughs in Understanding the Role of Functional Interactions Between the Neocortex and the Claustrum. Read the summary of the minisymposium written in collaboration with the other speakers in the Journal of Neuroscience here.
Maxime presents his work on the transcriptional heterogeneity of layer 6 corticothalamic neurons in somatosensory cortex th the 30th annual Barrels Conference held this year at Johns Hopkins. Join us next year in California for Barrels XXXI.
Solange presented the lab's work at a great Society for Claustrum Research meeting at George Washington University. Join us next year for the 5th Annual Symposium. Visit the Society's website for more details: www.claustrumsociety.org
The paper from Kai, Juhyun, Thomas and Stephanie is published in Nature showing that Lhx6-positive GABAergic neurons of the zona incerta promote sleep. This work was a collaboration with the Blackshaw lab as well as labs at UNC, MIT, the Francis Crick Institute and the NIMH. Here is the link: DOI: 10.1038/nature23663
Congratulations on a great team effort!
Juhyun's paper showing that increases in neuronal excitability are not restricted to cortical cell types that degenerate in Amyotrophic Lateral Sclerosis (ALS) was just published in the Journal of Neuroscience. These findings suggest that therapies for ALS may need to be tailored for different cell types and stages of disease. This work was a collaboration with the Hughes Lab at the University of Colorado, Ashwin Shetty and Paola Arlotta at Harvard, and the Bergles and Goff labs at Johns Hopkins. Here is the link: DOI: 10.1523/JNEUROSCI.0811-17.2017
The solar eclipse in the Baltimore-Washington Area!
Juhyun's work in collaboration with Abe Langseth and the Bergles lab on the cell-type specific expression of C9orf72, a gene linked to the neurodegenerative disease Amyotrophic Lateral Sclerosis, has been published.
Congratulations Abe and Juhyun!
See full article here: https://www.nature.com/articles/s41598-017-05864-2
Chanel defends her thesis and gives her public presentation. Congratulations to the first graduate from the lab! Chanel is completing an internship this summer at FASEB before officially handing in her thesis in the fall.
Ashley is joining the lab for the summer as a JHU-SIP fellow. Ashley is currently a senior at the University of Notre Dame who is majoring in Neuroscience and Behavior and minoring in Science, Technology and Values.
The Brown and Goff laboratories receive a grant from the National Science Foundation to determine cell-type specific gene expression differences induced by experience-dependent plasticity. Experiences in our environment affect the activity of genes expressed in neurons and lead to changes in brain circuits. How different cell types in the brain differ in their responses to changes in incoming sensory input is the focus of this study.
Congratulations to all who contributed to the grant!
Presented our work on the circuits of the claustrum. Thank you to the Salk for hosting and fostering lots of interesting discussions.
Maxime presents his work at Barrels XXIX in Los Angeles. Barrels XXX will be in Baltimore in 2017!
The laboratory receives a grant from the National Institute of Neurological Disorders and Stroke to understand the function of a poorly understood brain structure, the claustrum. The claustrum may play important roles in perception, attention, and sleep.
Congratulations to everyone who contributed to the grant proposal!
Maxime receives a Boehringer Ingelheim Fonds Ph.D. Fellowship.
Zulikayida Maimaiti joins the lab for the summer as an American Physiological Society STEP UP Fellow. Zuly just finished her freshman year at MIT where she is a Biological Engineering major.
Our work on the synaptic organization of the claustrum is published in the Journal of Neuroscience. The link is here: DOI:10.1523/JNEUROSCI.3643-15.2016
Congratulations Juhyun, Chanel and Richard!
Maxime passes his qualifying exam for the Ph.D. Program in Biochemistry, Cellular and Molecular Biology. Congratulations Maxime!
Dohee is accepted by Seoul National University College of Medicine, her top choice. Congratulations Dohee!
Jaclyn Frandolig joins the lab. Welcome Jaclyn!
Maxime Chevée officially joins the lab. Welcome Maxime!
Dohee was accepted into the prestigious Catholic University of Korea Medical School. Here is her formal application portrait. Congratulations Dohee!
Lab lunch thanking Lisle for his contributions to the lab over the summer. Lisle will start at the Medical College of Wisconsin this fall. Congratulations Lisle!
Spotlight on corticothalamic circuits: Juyhun's image is on the membership cards for the Society for Neuroscience!
Brandie Morris will be starting as a graduate student in the Department of Neuroscience at Thomas Jefferson University this fall. Congratulations Brandie!
Juhyun Kim won a first prize for his poster presentation at the Baltimore Society for Neuroscience meeting. Juhyun also presented his poster at the Society for Neuroscience Annual Meeting in Washington.
Kihwan Lee joins the lab. Kihwan received his Ph.D. from Seoul National University in 2014. He will be initially working on white matter neurons in the cortex.
BrainFacts.org features Juhyun Kim and Chanel Matney's image as the picture of the week.
The first paper from the lab featuring work by Juhyun Kim and Chanel Matney is published. Juhyun's image is even on the cover! The link can be found here: DOI:10.1523/JNEUROSCI.1325-14.2014
Solange Brown receives a Klingenstein-Simons Fellowship Award which will be used to understand the neural circuits regulating the cortical response to sensory input.
Robbie Callen, Daniel Gill and Eva Schulteis graduate!
Dohee Kim is awarded a Provost's Undergraduate Research Award for her work on amyotrophic lateral sclerosis.
Lab members run in the 2014 Fiesta 5K in support of the Packard Center for ALS Research. Come join us next year to support a great cause!
Daniel Gill will be joining the Department of Neuroscience at the University of Chicago for his graduate studies.
Eva Schulteis will be joining the Corporate Executive Board as an Analyst.
Congratulations Dan and Eva!
Solange Brown receives a NARSAD Young Investigator Award which will be used to support work on the role of white matter neurons in regulating cortical activity.
Eva Schulteis is awarded a Provost's Undergraduate Research Award for her work on white matter neurons and neuropsychiatric diseases.
Chanel Matney is awarded a Predoctoral Fellowship from the National Science Foundation
Chanel was also named as a finalist for the Robateau-Epps Fellowship and received an Honorable Mention from the Ford Foundation.